PO-05-234 AUTONOMIC DYSFUNCTION AFTER COVID-19 IMMUNIZATION - CASE REPORT
نویسندگان
چکیده
The infection caused by the SARS-CoV-2 continues affecting millions of people worldwide and vaccines to prevent coronavirus disease (COVID-19) are considered most promising approach for curbing pandemic. Otherwise, cardiovascular neurological complications associated with were speculated some few case reports published. We describe a postural orthostatic tachycardia syndrome (POTS) after viral vector COVID-19 vaccination possible autoimmune process syndrome. A 35-year-old female, without previous symptoms or comorbidities, developed intermittent palpitation, intense fatigue dyspnea, compromising her daily activities, triggered upright position, seven days following second dose Oxford vaccine. Physical examination was normal, except heart rate (HR) increase 33 beats/min from supine standing no significant change in blood pressure reproduction symptoms. 24-hour Holter monitoring revealed episodes spontaneous sinus correlated palpitation fatigue. Extensive diagnostic investigations excluded primary cardiac, endocrine, infectious rheumatologic etiologies. patient underwent an autonomic function test which demonstrated normal baroreflex sensitivity, as well cardiovagal adrenergic scores. Head-up tilt showed persistent (HR medium 84 position 126 during tilt), hypotension, consistent criteria POTS. According current guidelines, general behavior recommendations, pharmacotherapy low propranolol rehabilitation oriented. Along three months follow-up, reported gradually improvement POTS is heterogeneous disorder nervous system characterized intolerance. Although physiopathology vaccine disorders remains speculative, response one mechanisms. Based on clinic presentation, time frame symptom onset other well-known post-vaccination syndromes, may be indicator induced immunization. Further studies needed assess causal relationship between immunization dysfunction.
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2023
ISSN: ['1556-3871', '1547-5271']
DOI: https://doi.org/10.1016/j.hrthm.2023.03.1424